tert-butyl N-[(E)-benzylideneamino]carbamate

tert-butyl N-[(E)-benzylideneamino]carbamate - Names and Identifiers

Name	Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyl ester
Synonyms	N-Boc-N'-benzylidene-hydrazine Benzaldehyde (Tert-Butoxycarbonyl)Hydrazone tert-butyl N-[(E)-benzylideneamino]carbamate (E)-tert-Butyl 2-benzylidenehydrazinecarboxylate tert-Butyl (E)-2-benzylidenehydrazine-1-carboxylate N'-BENZYLIDENE-HYDRAZINECARBOXYLIC ACID TERT-BUTYL ESTER Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyl ester Hydrazinecarboxylic acid, 2-(phenylmethylene)-, 1,1-dimethylethyl ester
CAS	24469-50-9

tert-butyl N-[(E)-benzylideneamino]carbamate - Physico-chemical Properties

Molecular Formula	C12H16N2O2
Molar Mass	220.27
Density	1.03±0.1 g/cm3(Predicted)
Melting Point	185-187 °C(Solv: ethanol (64-17-5))
pKa	10.32±0.46(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C

tert-butyl N-[(E)-benzylideneamino]carbamate - Introduction

Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyl ester(Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyl ester) is an organic compound with the following properties:

1. Appearance: It is a colorless to yellowish solid.

2. Solubility: Soluble in organic solvents such as methanol, ether and dichloromethane, but insoluble in water.

3. Melting point: about 70 ° C.

4. Chemical properties: it is a kind of electrophilic reagent, can react with Nucleophilic Reagents, such as alcohol, phenol, Amine and so on.

The main uses of Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyl ester are as follows:

1. As an intermediate: it can be used to synthesize a variety of organic compounds, such as drugs and pesticides.

2. Protecting group: Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyl ester can be used as a protecting group to protect compounds containing active hydrogen (such as amines and alcohols), to prevent non-selective reactions in the reaction.

The method of preparing Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyyl ester is as follows:

1. Benzaldehyde and dimethylformamide were mixed in a cooled environment, and excess sodium bicarbonate and sodium hydride were slowly added.

2. Add an appropriate amount of cuprous chloride as a catalyst and continue to stir the reaction mixture.

3. After completion of the reaction, the mixture was filtered to remove the residue.

4. The cooled filtrate is extracted with ether, and then purified by distillation and crystallization to obtain Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyyl ester.

regarding safety information, Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimenthylethyl ester has certain risks, and the following aspects should be paid attention:

1. Toxicity: Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyl ester may cause irritation and damage to skin, eyes and respiratory tract. Use should take appropriate precautions, such as wearing safety glasses and gloves, and maintain ventilation.

2. Explosive: Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyl ester is a flammable substance, should avoid contact with the fire source, and stored in a cool, ventilated place.

3. Storage and handling: The Hydrazinecarboxylic acid, (phenylmethylene)-, 1,1-dimethylethyl ester should be stored in a sealed container, away from oxidizing agents and acids. Dispose of waste in accordance with local regulations.

Last Update：2024-04-09 21:21:28